Pulmonary arteriovenous shunting in the normal fetal lung

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Pulmonary arteriovenous shunting in the normal fetal lung.

OBJECTIVES We hypothesized that pulmonary arteriovenous shunting (PAVS) is normally present in fetal lungs and that cavopulmonary anastomosis-induced PAVS may represent a return to an earlier morphologic stage of development. BACKGROUND The surgical superior cavopulmonary anastomosis is performed as part of the staged Fontan pathway to treat univentricular forms of congenital heart disease; P...

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Bubble contrast echocardiography in detecting pulmonary arteriovenous shunting in children with univentricular heart after cavopulmonary anastomosis.

OBJECTIVES We sought to compare bubble contrast echocardiography and pulmonary angiography in detecting pulmonary arteriovenous malformation (PAVM) in children with cavopulmonary anastomosis (CPA), and to examine anatomic and physiologic variables associated with the development of PAVM. BACKGROUND Development of PAVM in patients with CPA may cause profound cyanosis. Pulmonary arteriovenous m...

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Postmortem demonstration of intrapulmonary arteriovenous shunting.

The measurement of the pressure required to drive a 2% solution of gelatin across the pulmonary vascular bed of a group of 49 infants dying suddenly at less than 44 weeks' postnatal age, has shown the presence of low pressure arteriovenous shunting in 30 cases (61%). Injection of polymethylmethacrylate beads in three cases has demonstrated that the vessels that form the shunts are up to 60 micr...

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Hypoxia-induced intrapulmonary arteriovenous shunting at rest in healthy humans.

Intrapulmonary arteriovenous (IPAV) shunting has been shown to occur at rest in some subjects breathing a hypoxic gas mixture [fraction of inspired oxygen (FI(O(2))) = 0.12] for brief periods of time. In the present study we set out to determine if IPAV shunting could be induced at rest in all subjects exposed to hypoxia for 30 min. Twelve subjects (6 women) breathed four levels of hypoxia (FI(...

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Exercise-induced intrapulmonary arteriovenous shunting in healthy humans.

We hypothesized that increasing exercise intensity recruits dormant arteriovenous intrapulmonary shunts, which may contribute to the widened alveolar-arterial oxygen difference seen with exercise. Twenty-three healthy volunteers (13 men and 10 women, aged 23-48 yr) with normal lung function and a wide range of fitness (mean maximal oxygen uptake = 126% predicted; range = 78-200% predicted) were...

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ژورنال

عنوان ژورنال: Journal of the American College of Cardiology

سال: 2004

ISSN: 0735-1097

DOI: 10.1016/j.jacc.2004.06.064